I had the opportunity to participate in the Summer Institute of Biostatistics and Data Science (SIBDS) at Columbia University during the summer of 2023. I worked with Dr. Caleb Miles and Shukria Zaman to compare the effectiveness of newer antipsychotic medications relative to older medications in their effect on health outcomes in patients with schizophrenia. To do so, we used data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE).
We considered different approaches to adjusting for noncompliance, since the study design allowed patients to change their medication over the course of the study. We also examined treatment effect heterogeneity to understand whether some patients would do better on one medication versus another, or whether the magnitude of the effect varied depending on patient characteristics.